Endocrine Abstracts

The notable expression of the androgen receptor (AR) in breast cancer suggests an important biological role and, hence, a window of utilizing it as a therapeutic target. Due to the undesirable side effects of AR agonists, attempts have been undertaken to develop tissue-selective androgen receptor modulators (SARMs). One such SARM is Cl-4AS-1, which has previously been shown to behave similar to the natural AR agonist, dihydrotestosterone (DHT). We aimed to examine the effects ...

MicroRNA molecules (miRNAs) have important roles in regulating cell behavior. In addition, their expression levels can be used in tumor classification. The expression of miRNAs has been to be regulated by the androgen receptor (AR), which seems to play an interesting role in the tumorigenic process of breast cancer. We hypothesized that AR may control the behavior of breast cancer cells via modulating the expression of miRNAs. Using PCR arrays, we examined the differential exp...